STL to Knoxville TN
Join 450,000+ happy customers who saved on flights
Cheap Flights to Popular Destinations
Getaway Flights from STL to Knoxville TN
Travel Tips for Your STL to Knoxville Trip
Traveling is exciting, but a little preparation can make your trip even smoother. Pack light and only bring what you really need while leaving some room for Smoky Mountain souvenirs. Keep digital and physical copies of important documents like your ID and rental car reservation. Learn a few Tennessee phrases like "y'all" and "mighty pretty" to connect with locals. Stay flexible because mountain weather can change quickly embrace the unexpected detours. Try local specialties like St. Louis toasted ravioli and Knoxville's famous tomato pie, but be mindful of food safety. Always have some cash for rural tolls and farmers' markets, but keep it in multiple places. Most importantly, enjoy those Blue Ridge Mountain views put the phone down and breathe in that fresh mountain air.
Travel Deals For STL to Knoxville TN
Low Cost Flights To Trending Destinations
STL to Knoxville Safety Tips
Staying safe on this Midwest-to Appalachia journey is about smart preparation. Keep valuables out of sight when exploring St. Louis' Gateway Arch or Knoxville's Market Square. Research rest stops along I-64 and I-75 the Marion Welcome Center is particularly safe. Trust your instincts if a mountain road looks too isolated after dark. Share your itinerary with someone back home, especially if hiking in the Smokies. Save these numbers in your phone: St. Louis Police Non-Emergency: 314-231-1212 Knoxville Police Non-Emergency: 865-215-7000 Remember: bear spray isn't usually needed, but making noise on trails keeps wildlife away.
Flight deals to popular destinations
Los Angeles
Explore the iconic Hollywood Walk of Fame and snap a picture with your favorite celebrity’s star before heading up to Griffith Observatory for breathtaking views of the city and the Hollywood Sign.
Miami
Relax on the famous South Beach, soaking up the sun, swimming in crystal-clear waters, and strolling along the lively Ocean Drive. Take a boat tour around Biscayne Bay to catch stunning views of the skyline.
New York
Visit Times Square at night to experience the dazzling lights, street performances, and iconic Broadway theaters. Take the Staten Island Ferry for a free ride with stunning views of the Statue of Liberty
Las Vegas
Experience the dazzling lights of the Las Vegas Strip by exploring world-famous casinos, watching mesmerizing fountain shows at the Bellagio, and catching a top-tier Cirque du Soleil performance.
Explore STL to Knoxville TN with Explorria
This 500-mile journey blends urban energy with Appalachian charm. Start beneath St. Louis’ soaring Gateway Arch before heading southeast through:
- Nashville: Country music history and hot chicken
- Crossville: The “Golf Capital of Tennessee”
- Oak Ridge: Fascinating atomic history
Arrive in Knoxville, where the University of Tennessee buzz meets Smoky Mountain serenity. Don’t miss:
✓ Market Square’s vibrant dining scene
✓ Ijams Nature Center’s urban wilderness
✓ Sunsphere Tower’s panoramic views
Frequently Asked Questions
Q: How long does it take to drive from Wichita to San Antonio?
A: The direct route via I-35 S takes 7-8 hours, but we recommend allowing 2-3 days to fully enjoy stops like Oklahoma City’s Bricktown and the Wichita Mountains Wildlife Refuge.
Q: What’s the most scenic alternate route?
A: For breathtaking views, take US-281 S through the Texas Hill Country, passing through charming towns like Marble Falls and stunning landscapes like Enchanted Rock.
Q: What’s the #1 can’t-miss stop along the way?
A: Don’t miss the Wichita Mountains Wildlife Refuge in Oklahoma—home to free-roaming bison, scenic hiking trails, and the historic Holy City of the Wichitas.
Q: Where’s the best quick meal in Oklahoma City?
A: Grab legendary onion burgers at Tucker’s Onion Burgers (a local institution since 1946) or authentic Mexican street tacos at Barrios Fine Mexican Dishes.
Q: Do I need special tires for this route?
A: Standard tires work year-round, but if traveling December-February, check for ice warnings in northern Texas and Oklahoma.
Q: Are there dangerous animals to watch for?
A: Deer crossings are common at dawn/dusk—especially near rural areas. In Texas, watch for armadillos (they can damage tires if hit).
Q: Best time to avoid San Antonio traffic?
A: Arrive before 3 PM to miss I-35 rush hour congestion near downtown.
Q: Any toll roads to plan for?
A: Yes—have $5-10 in change ready for Oklahoma’s Turner Turnpike and Texas’ I-35 express lanes.